Molecular biology
We employ genomic, genetic and biochemical approaches to investigate the molecular basis of phenotypic evolution.
Molecular biology themes of interest include:
external pageCooperation and Cheating among Germinating Spores
S Pande, PP Escriva, YTN Yu, U Sauer, GJ Velicer 2020. Current Biology
external pageSocial genes are selection hotspots in kin groups of a soil microbe
Wielgoss S, R Wolfensberger, L Sun, F Fiegna, GJ Velicer. 2019. Science
external pageBacterial predator-prey coevolution selects on virulence-associated prey defenses
Nair RR, M Vasse, S Wielgoss, L Sun, Y-TN Yu, GJ Velicer. 2019. Nature Communications
external pageAdaptive evolution of an sRNA that controls Myxococcus development
Yu YTN, X Yuan and GJ Velicer. 2010. Science
external pageDiscovering the hidden secondary metabolome of Myxococcus xanthus: a study of intra-specific diversity
Krug D, G Zurek, O Revermann, M Vos, GJ Velicer and R Müller. 2008. Applied & Environmental Microbiology
external pageEvolution of an obligate social cheater to a superior cooperator
Fiegna F, YTN Yu, SV Kadam and GJ Velicer. 2006. Nature
external pageEvolution of novel cooperative swarming in the bacterium Myxococcus xanthus
Velicer GJ and YTN Yu. 2003. Nature
external pageRescue of social motility lost during evolution of Myxococcus xanthus in an asocial environment
Velicer GJ, RE Lenski and L Kroos. 2002. Journal of Bacteriology
external pageRibonuclease D Processes a Small RNA Regulator of Multicellular Development in Myxobacteria
SM Cossey, GJ Velicer, YTN Yu. 2023. Genes
external pageMutation of rpoB shifts the nutrient threshold triggering myxococcus multicellular development
SA Eisner, GJ Velicer, YTN Yu. 2022. Frontiers in Microbiology
external pagesRNA‐pathway genes regulating myxobacterial development exhibit clade‐specific evolution
Chen ICK, BM Satinsky, GJ Velicer, YTN Yu. 2019. Evolution & Development
external pageA conserved stem of the Myxococcus xanthu sRNA Pxr controls sRNA accumulation and multicellular development
Yu YTN, E Cooper and GJ Velicer. 2017.Scientific Reports
external pageDivergence of functional effects among bacterial sRNA paralogs
Chen ICK, GJ Velicer and YTN Yu. 2017. BMC Evolutionary Biology
external pageSpontaneous reversions of an evolutionary trait loss reveal regulators of an sRNA that controls multicellular development in the myxobacteria
Yu YTN, M Kleiner and GJ Velicer. 2016. Journal of Bacteriology
external pageA recent evolutionary origin of a bacterial small RNA that controls multicellular fruiting body development
Chen ICK, B Griesenauer, YTN Yu and GJ Velicer. 2014. Molecular Phylogenetics and Evolution
external pageAdaptive evolution of an sRNA that controls Myxococcus development
Yu YTN, X Yuan and GJ Velicer. 2010. Science
external pageIdentification of the Ω4514 regulatory region, a developmental promoter of Myxococcus xanthus that is transcribed in vitro by the major vegetative RNA polymerase
Hao T, D Biran, GJ Velicer and L Kroos. 2002. Journal of Bacteriology